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Introducing BERBELLE

Metabolic wellness, backed by research, made simple.

1,200 mg Berberine HCl + 100 mg Ceylon Cinnamon in one daily formula. These are ingredients that have been studied in human trials for glucose metabolism and metabolic health.

Shop BERBELLESee the Research
✓ 1,200 mg berberine per serving✓ Low-coumarin Ceylon cinnamon✓ Made for the UK confirm
Berberine HCl 1,200 mg Ceylon Cinnamon 100 mg
VitalbolicsBERBELLEBerberine HCl
+ Ceylon Cinnamon
Food supplement
🔬Ingredient research summarised
🌿Ceylon, not cassia
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Why BERBELLE

Two ingredients. No guesswork.

We built BERBELLE around a dose researchers actually use, and we explain the science honestly, including its limits.

1,200 mg

A research-range dose

Our berberine dose sits within the 0.9–1.5 g/day range most commonly used in clinical trials.

Source: 2024 meta-analysis
Ceylon

The "true" cinnamon

We use Ceylon cinnamon, which contains only trace coumarin compared with the cheaper cassia cinnamon.

Source: ingredient composition data
100%

Transparent science

We publish the research on our ingredients, including studies that found no effect.

See: Our Science
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A simple daily routine

Built to fit around real life

Take BERBELLE with meals as part of a balanced diet and active lifestyle. There's no complicated protocol, just a consistent daily habit.

  • Take with food confirm serving: _ capsules
  • Stay consistent. Most studies ran for 8–12 weeks.
  • Subscribe so you never run out
Start Your Routine
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The research at a glance

What published human studies have looked at

These are studies of berberine and cinnamon as ingredients, not trials of BERBELLE itself.

Supportive

Insulin-resistance markers

Multiple RCT meta-analyses of berberine

Supportive

Glucose metabolism

Fasting glucose & HbA1c in studied groups

Supportive

Blood lipids

LDL-C and triglycerides in some populations

Limited–moderate

Body weight

Modest average effects; results are mixed

Read the full research summary

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Limited-time bundle

Buy 2, Get 1 Free

Three months of BERBELLE, the length of a typical study period, at our best price.

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🔬 Ingredient research-backed 1,200 mg Berberine
VitalbolicsBERBELLEBerberine HCl
+ Ceylon Cinnamon
Food supplement
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BERBELLE

Berberine HCl 1,200 mg + Ceylon Cinnamon 100 mg

The plant compound behind 20+ clinical trials, now in one clean daily formula. Pair it with a balanced diet and active lifestyle to support your metabolic wellness routine.

  • 1,200 mg Berberine HCl, within the most-studied clinical range
  • Ceylon cinnamon, the low-coumarin "true" cinnamon
  • Transparent science: we publish the research and its limits
  • Vegan-friendly · No unnecessary fillers confirm
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1 Bottle

1-month supply

£34.99
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3-month supply · £23.33 per bottle

£69.98£104.97SAVE £34.99
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5-month supply · £20.99 per bottle

£104.97£174.95SAVE £69.98

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Frequently asked questions

What's in BERBELLE?

Each serving contains 1,200 mg Berberine HCl and 100 mg Ceylon cinnamon (Cinnamomum verum). confirm capsule shell & other ingredients

How do I take it?

Take _ capsules daily with meals and water. Do not exceed the recommended daily dose. Food supplements should not replace a varied, balanced diet and healthy lifestyle.

Is BERBELLE clinically proven?

We're honest about this. Berberine and cinnamon have been studied extensively as ingredients in published human trials, but the exact BERBELLE formula has not been tested in its own clinical trial. You can read the full research summary, including the limitations, on our Science page.

How long should I take it?

Consistency matters. Most published berberine studies ran for 8–12 weeks or longer, which is why many customers choose the 3-month bundle.

Why Ceylon cinnamon instead of regular cinnamon?

Most supermarket cinnamon is cassia, which can contain considerably more coumarin. Ceylon ("true") cinnamon generally contains only trace amounts, making it our choice for daily use.

Are there any side effects?

The most commonly reported effects of berberine are digestive: nausea, stomach discomfort, bloating, constipation or diarrhoea. Taking it with food may help. Stop use and speak to a healthcare professional if you have concerns.

Can I take it with medication?

Berberine can interact with some medicines. If you take any medication, especially for blood sugar, speak to your doctor or pharmacist before use. Not suitable during pregnancy or breastfeeding, or for children.

How does the monthly subscription work?

You're charged and sent a new bottle every 30 days at 15% off. There's no minimum term: pause, skip or cancel anytime from your account before your next billing date.

Delivery & returns

UK orders are dispatched within _ working days. Free delivery on bundles. See our Returns Policy for our money-back guarantee terms. confirm

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The problem

Modern life isn't built for metabolic health

Long hours sitting down, processed carbs, poor sleep and constant stress. After 30, it can feel like your body stops cooperating, even when you're trying.

🍞

Carb-heavy days

Convenience food makes up much of the modern diet, and it's hard to stay on track.

🪑

Sitting all day

Desk jobs and screen time mean far less daily movement than our bodies are built for.

🌀

Too much conflicting advice

Fad products make big promises with little science behind them. It's hard to know what to trust.

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The solution

A smarter daily routine, built on research

BERBELLE doesn't promise miracles. It gives you two well-researched ingredients at a transparent dose to support a healthier routine.

Research-range berberine

1,200 mg per serving, within the 0.9–1.5 g/day range most commonly studied in human trials.

Paired with Ceylon cinnamon

A traditional botanical, chosen in its low-coumarin Ceylon form for daily use.

Plus the basics that matter

Take with meals alongside a balanced diet and regular movement. Supplements work best as part of a lifestyle, not instead of one.

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The research in numbers

Why researchers keep studying berberine

These figures come from published ingredient studies, not trials of BERBELLE.

20randomised controlled trials pooled in a 2023 berberine meta-analysisn = 1,761 participants
0.9–1.5 gdaily berberine range most used in clinical trials2024 meta-analysis
1,200 mgberberine dose used in a 2025 12-week randomised trial with cinnamonMansour et al., Eur J Nutr 2025
23RCTs reviewed in a 2025 meta-analysis on body-weight measuresModest average effects

Read the full research summary →

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Your 90-day routine

What to expect

Everyone is different. This is how to get the most from BERBELLE.

Week 1

Start taking BERBELLE with meals. Taking it with food helps your stomach adjust.

Weeks 2–4

Make it a habit. Pair it with balanced meals and a daily walk.

Weeks 5–8

Stay consistent. Research effects were more apparent beyond 8 weeks.

Week 12

The length of a typical study period. That's why our 3-month bundle is the most popular.

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Why BERBELLE

Not all berberine supplements are equal

BERBELLETypical berberine brands
Clearly stated 1,200 mg berberine dose✓Varies
Ceylon (low-coumarin) cinnamon✓Often cassia or none
Published research summary with limitations✓✕
No "miracle fat-burner" claims✓✕
Flexible monthly subscription✓Some
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Reviews

What our customers say

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Our most popular offer

Start your 90-day BERBELLE routine

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Our Science

Explore the research behind our ingredients.

A transparent summary of published human studies on berberine and cinnamon. It covers what the research shows and where the evidence is still developing.

Important: This page summarises published research on berberine and cinnamon as ingredients. It is not proof that BERBELLE prevents, treats or cures any disease. The exact BERBELLE formula (1,200 mg berberine + 100 mg Ceylon cinnamon) has not yet been tested in a published randomised clinical trial. Evidence reviewed through August 2026.
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Our formula vs the research

How closely does the research match BERBELLE?

1,200 mg

Berberine HCl

✓ Within common clinical range. A 2024 meta-analysis found 0.9–1.5 g/day was the most common dose used in trials.

100 mg

Ceylon Cinnamon

Lower than most cinnamon trials. Many trials use gram-level doses, so this amount is not treated as independently dose-proven. We use Ceylon for its low coumarin content.

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Evidence overview

What the research shows, and its limits

Area studiedEvidence levelWhat the research showsKey limitation
Insulin-resistance markers (HOMA-IR)SupportiveMultiple RCT meta-analyses report reductions in HOMA-IR and fasting insulin with berberine.Studied in metabolic populations. Not a disease-treatment claim.
Fasting glucose / HbA1cSupportiveModest reductions in meta-analyses. A 2025 RCT (1,200 mg berberine + 600 mg cinnamon) improved both vs placebo.That trial used 600 mg cinnamon, not 100 mg.
Blood lipidsSupportiveReductions in LDL-C and/or triglycerides in some metabolic populations.Results vary by population and study.
Liver-related markersPromisingNAFLD meta-analyses report improvements in liver enzymes, HOMA-IR, BMI and lipids.Applies to clinical populations. Individual trials are inconsistent.
Body weightLimited–moderateRecent meta-analysis: ~0.88 kg average reduction. Earlier reviews are mixed.A 2026 RCT found no visceral-fat reduction at 1 g/day.
Ceylon cinnamon at 100 mgInsufficient dose dataCinnamon research is mixed and mostly uses ~0.12–6 g/day. Stronger effects are reported above 1.5 g/day.Not independently proven at 100 mg.
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Key studies

The studies behind the story

We include studies with null findings too, because an honest picture matters more than a selective one.

Ingredient research · not a trial of BERBELLE

Berberine & insulin-related markers

2023 meta-analysis of 20 RCTs (n=1,761): berberine lowered fasting insulin by 2.36 mU/L and HOMA-IR by 0.85 vs placebo on average.

Systematic review & meta-analysis · PMID 37598753
Ingredient research · not a trial of BERBELLE

Berberine + cinnamon combination

1,200 mg berberine + 600 mg cinnamon daily for 12 weeks significantly lowered fasting blood sugar, HbA1c and LDL-C vs placebo in people with type 2 diabetes. No difference was found in other metabolic or body measures.

Mansour et al., Eur J Nutr 2025 · PMID 39998703
Ingredient research · not a trial of BERBELLE

Berberine & glucose

2023 meta-analysis: fasting glucose fell by 0.52 mmol/L and HbA1c by ~0.41 percentage points vs placebo across included trials.

Meta-analysis of RCTs · 2023
Ingredient research · not a trial of BERBELLE

Body-weight measures

2025 meta-analysis of 23 RCTs: average change of −0.88 kg body weight, −0.48 BMI and ~−1.32 cm waist vs control. The authors noted study-quality limitations.

Systematic review & meta-analysis · PMID 41310257
Null finding · shown for transparency

Visceral fat: no reduction

A large 2026 RCT (337 adults) found 1 g/day berberine for 6 months did not reduce visceral fat or liver fat vs placebo, although LDL-C, apoB and hs-CRP improved modestly.

Randomised clinical trial · PMID 41543854
Ingredient research · not a trial of BERBELLE

Cinnamon & glycaemic markers

2023 meta-analysis of 24 RCTs: cinnamon improved fasting blood sugar, HOMA-IR and HbA1c, but not serum insulin. Doses and formulations varied widely.

Dose-response meta-analysis · PMID 37818728
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How it may work

The mechanisms researchers study

Laboratory and animal research suggests berberine may act on AMPK-related energy sensing, liver glucose production, lipid metabolism and the gut microbiota. Cinnamon research looks at glucose transport and insulin-signalling pathways.

Please note: these mechanisms explain why scientists study these ingredients. They do not prove that any individual will experience a specific result.

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Safety & responsible use

Use BERBELLE responsibly

  • The most commonly reported effects are digestive: nausea, stomach discomfort, bloating, constipation or diarrhoea.
  • Berberine can interact with medicines. Speak to a healthcare professional if you take any medication.
  • If you use glucose-lowering medication, seek clinical advice before use.
  • Not suitable during pregnancy or breastfeeding, or for infants and children.
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References (13 sources)
  1. Mansour A, et al. Berberine + cinnamon in type 2 diabetes: RCT. Eur J Nutr. 2025;64(2):102. PMID 39998703.
  2. Overall and sex-specific effect of berberine on glycemic and insulin-related traits: SR & MA of RCTs. 2023. PMID 37598753.
  3. The effect of berberine on obesity indices: SR & MA. 2025. PMID 41310257.
  4. Berberine and adiposity in diabetes-free individuals with obesity and MASLD: RCT. 2026. PMID 41543854.
  5. Berberine supplementation and cardiovascular risk factors in adults: SR & dose-response MA. 2022. PMID 36313096.
  6. Clinical efficacy and safety of berberine in NAFLD: MA & SR. 2024. PMID 38429794.
  7. Yan HM, et al. Efficacy of berberine in patients with NAFLD. PLoS One. 2015. PMID 26252777.
  8. Updated SR & dose-response MA of cinnamon supplementation and glycemic control in T2DM. 2023. PMID 37818728.
  9. Effects of cinnamon on patients with metabolic diseases: umbrella review. 2025. PMID 41256917.
  10. NCCIH. Berberine and Weight Loss: What You Need To Know.
  11. NCCIH. Diabetes and Dietary Supplements: What You Need To Know.
  12. GOV.UK. Great Britain nutrition and health claims register.
  13. ASA/CAP. Food, food supplements and associated health or nutrition claims, Section 15.

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Ingredients

Two ingredients. Fully disclosed.

No proprietary blends and no hidden doses. Here's exactly what's in every serving of BERBELLE, and why.

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1,200mg per serving
Ingredient 01

Berberine HCl

Berberine is a bright-yellow compound found in plants such as barberry, goldenseal and Chinese goldthread, and it has a long history in traditional use. Today it's one of the most-studied botanical compounds in human metabolic research.

  • Dose sits within the 0.9–1.5 g/day range most used in clinical trials
  • Studied in meta-analyses of RCTs for glucose metabolism, insulin-resistance markers and blood lipids
  • Hydrochloride (HCl) form, the form commonly used in research

Source: confirm plant source, e.g. Berberis aristata

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100mg per serving
Ingredient 02

Ceylon Cinnamon (Cinnamomum verum)

Known as "true cinnamon", Ceylon comes mainly from Sri Lanka. Most cinnamon in supermarkets is cassia, which can contain considerably more coumarin. Ceylon generally contains only trace amounts, so it's our choice for a product taken every day.

  • Low-coumarin Ceylon species, not cassia
  • A traditional botanical that researchers have studied alongside berberine
  • Complements berberine in a simple two-ingredient formula

Our 100 mg dose is lower than most cinnamon studies. We say so on our Science page.

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Supplement Facts

Serving size_ capsules
Servings per container_
Per servingAmount
Berberine HCl1,200 mg
Ceylon Cinnamon (Cinnamomum verum)100 mg

Other ingredients: confirm from label

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What's not inside

Clean by design

No proprietary blendsNo cassia cinnamonVegan-friendly ?Gluten-free ?No artificial colours ?GMP-certified facility ?

Not suitable during pregnancy or breastfeeding, or for children. Consult a healthcare professional if you take medication.

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See the research, then decide

Everything we know about our ingredients, in plain English.

Shop BERBELLE Our Science

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